Looking into the issue, I don't know. Sorry with the lack of replies, there's just not enough information to really understand.

I'd recommend sending us your complete specs (OS, ram, gpu, cpu, ect) and running a game install verification. You can also check Event Viewer for application crashes and send us any information you can get.

Install Verification

Download the Lucas Simpsons Hit & Run Install Verifier the use the following instructions.

1. If "Lucas Simpsons Hit & Run Mod Launcher.exe", its "Hacks" folder or its "Mods" folder are in your game directory, move them elsewhere until after the verification is complete. Do not make any other changes to your game directory in preparation.
2. Open "Lucas' Simpsons Hit & Run Install Verifier.exe" and click Start and wait for it to complete.
3. After it completes, it should automatically show a "Save As" Dialogue Box. Save the file somewhere on your computer.
4. Submit the file to this Dropbox request